Comparative analysis of seven multiple protein sequence alignment servers: clues to enhance reliability of predictions. | Zendy

Pascal Briffeuil | Zendy; G Baudoux | Zendy; Christophe Lambert | Zendy; Xavier De Bolle | Zendy; C. Vinals | Zendy; Ernest Feytmans | Zendy; Eric Depiereux | Zendy

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Comparative analysis of seven multiple protein sequence alignment servers: clues to enhance reliability of predictions.

Author(s) -

Pascal Briffeuil,

G Baudoux,

Christophe Lambert,

Xavier De Bolle,

C. Vinals,

Ernest Feytmans,

Eric Depiereux

Publication year - 1998

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/14.4.357

Subject(s) - computer science , reliability (semiconductor) , confidence interval , multiple sequence alignment , server , sequence (biology) , the internet , data mining , sensitivity (control systems) , identification (biology) , identity (music) , power (physics) , sequence alignment , statistics , mathematics , biology , genetics , gene , computer network , peptide sequence , physics , botany , quantum mechanics , electronic engineering , world wide web , acoustics , engineering

The prediction reliability of seven multiple alignment servers currently available on the Internet (ClustalW, MAP, PIMA, Block Maker, MSA, MEME and Match-Box) has been evaluated in terms of power (sensitivity) and confidence (selectivity). Therefore, the alignments obtained have been respectively compared to refined structural alignments for 20 families of related proteins with low levels of identity.

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