Towards detection of orthologues in sequence databases. | Zendy

Yan P. Yuan | Zendy; Oliver Eulenstein | Zendy; Martin Vingron | Zendy; Peer Bork | Zendy

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Towards detection of orthologues in sequence databases.

Author(s) -

Yan P. Yuan,

Oliver Eulenstein,

Martin Vingron,

Peer Bork

Publication year - 1998

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/14.3.285

Subject(s) - phylogenetic tree , tree (set theory) , biology , construct (python library) , gene , sequence (biology) , computational biology , parsing , phylogenetics , genetics , database , computer science , artificial intelligence , combinatorics , mathematics , programming language

Numerous homologous sequences from diverse species can be retrieved from databases using programs such as BLAST. However, due to multigene families, evolutionary relationship often cannot be easily determined and proper functional assignment becomes difficult. Thus, discrimination between orthologues and paralogues within BLAST output lists of homologous sequences becomes more and more important.

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