Incremental threading optimization (TITO) to help alignment and modelling of remote homologues. | Zendy

Gilles Labesse | Zendy; JeanPaul Mor | Zendy

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Incremental threading optimization (TITO) to help alignment and modelling of remote homologues.

Author(s) -

Gilles Labesse,

JeanPaul Mor

Publication year - 1998

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/14.2.206

Subject(s) - threading (protein sequence) , computer science , sequence alignment , sequence (biology) , multiple sequence alignment , alignment free sequence analysis , biology , protein structure , peptide sequence , genetics , biochemistry , gene

Protein sequence comparison has become a major tool for biologists. Various methods have been designed in order to reveal even remote homologies among proteins. Sequence analyses are powerful, but the lower the identity score, the more skill and time are required to perform them accurately. While necessary to confirm the sequence comparison through the potential of mean force, sequence alignment and molecular modelling are still tedious and time-consuming tasks.

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