A Brownian dynamics model for the chromatin fiber | Zendy

L. Ehrlich | Zendy; C. Mükel | Zendy; Giuseppe Chirico | Zendy; Jörg Langowski | Zendy

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A Brownian dynamics model for the chromatin fiber

Author(s) -

L. Ehrlich,

C. Mükel,

Giuseppe Chirico,

Jörg Langowski

Publication year - 1997

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/13.3.271

Subject(s) - brownian dynamics , linker dna , chromatin , nucleosome , fiber , electrostatics , ionic strength , computer science , statistical physics , coulomb , brownian motion , physics , folding (dsp implementation) , biological system , chemical physics , dna , materials science , chemistry , biology , genetics , quantum mechanics , composite material , aqueous solution , electrical engineering , engineering , electron

We describe a Brownian dynamics model for the folding of the chromatin fiber based on the model of Woodcock et al. (Proc Natl Acad Sci USA, 90, 9021-9025, 1993). The model takes into account the elastic properties of the DNA as well as the electrostatic interaction and nucleosomal excluded-volume interaction. The solvent is described as a viscous medium, the electrostatic interactions by a screened Coulomb potential.

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