Match-Box_server: a multiple sequence alignment tool placing emphasis on reliability | Zendy

Eric Depiereux | Zendy; G. Baudoux | Zendy; Pascal Briffeuil | Zendy; Isabelle Reginster | Zendy; Xavier De Bolle | Zendy; Carla Vinals | Zendy; Ernest Feytmans | Zendy

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Match-Box_server: a multiple sequence alignment tool placing emphasis on reliability

Author(s) -

Eric Depiereux,

G. Baudoux,

Pascal Briffeuil,

Isabelle Reginster,

Xavier De Bolle,

Carla Vinals,

Ernest Feytmans

Publication year - 1997

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/13.3.249

Subject(s) - computer science , sequence alignment , similarity (geometry) , sequence (biology) , software , sequence analysis , computational biology , web server , reliability (semiconductor) , spec# , genetics , algorithm , biology , data mining , artificial intelligence , dna , gene , peptide sequence , the internet , world wide web , image (mathematics) , programming language , power (physics) , physics , quantum mechanics

The Match-Box software comprises protein sequence alignment tools based on strict statistical thresholds of similarity between protein segments. The method circumvents the gap penalty requirement: gaps being the result of the alignment and not a governing parameter of the procedure. The reliable conserved regions outlined by Match-Box are particularly relevant for homology modelling of protein structures, prediction of essential residues for site-directed mutagenesis and oligonucleotide design for cloning homologous genes by polymerase chain reaction (PCR).

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