Hybrid modelling of biological systems: current progress and future prospects | Zendy

Fei Liu | Zendy; Monika Heiner | Zendy; David Gilbert | Zendy

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Hybrid modelling of biological systems: current progress and future prospects

Author(s) -

Fei Liu,

Monika Heiner,

David Gilbert

Publication year - 2022

Publication title -

briefings in bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.204

H-Index - 113

eISSN - 1477-4054

pISSN - 1467-5463

DOI - 10.1093/bib/bbac081

Subject(s) - current (fluid) , computer science , biochemical engineering , engineering , geology , oceanography

Integrated modelling of biological systems is becoming a necessity for constructing models containing the major biochemical processes of such systems in order to obtain a holistic understanding of their dynamics and to elucidate emergent behaviours. Hybrid modelling methods are crucial to achieve integrated modelling of biological systems. This paper reviews currently popular hybrid modelling methods, developed for systems biology, mainly revealing why they are proposed, how they are formed from single modelling formalisms and how to simulate them. By doing this, we identify future research requirements regarding hybrid approaches for further promoting integrated modelling of biological systems.

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