Exploring protein domain structure | Zendy

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Exploring protein domain structure

Author(s) -

Jon Ison

Publication year - 2000

Publication title -

briefings in bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.204

H-Index - 113

eISSN - 1477-4054

pISSN - 1467-5463

DOI - 10.1093/bib/1.3.305

Subject(s) - domain (mathematical analysis) , protein domain , protein structure database , computer science , protein structure , annotation , computational biology , protein function prediction , structural genomics , protein function , function (biology) , genome , biology , artificial intelligence , genetics , gene , mathematics , sequence database , mathematical analysis , biochemistry

The protein databank contains coordinates of over 10,000 protein structures, which constitute more than 25,000 structural domains in total. The investigation of protein structural, functional and evolutionary relationships is fundamental to many important fields in bioinformatics research, and will be crucial in determining the function of the human and other genomes. This review describes the SCOP and CATH databases of protein structure classification, which define, classify and annotate each domain in the protein databank. The hierarchical structure, use and annotation of the databases are explained. Other tools for exploring protein structure relationships are also described.

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