RNA structure interactions and ribonucleoprotein processes of the influenza A virus | Zendy

Wayne Dawson | Zendy; Michał Łaźniewski | Zendy; Dariusz Plewczyński | Zendy

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RNA structure interactions and ribonucleoprotein processes of the influenza A virus

Author(s) -

Wayne Dawson,

Michał Łaźniewski,

Dariusz Plewczyński

Publication year - 2017

Publication title -

briefings in functional genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.22

H-Index - 67

eISSN - 2041-2647

pISSN - 2041-2649

DOI - 10.1093/bfgp/elx028

Subject(s) - biology , rna , ribonucleoprotein , rna splicing , virus , transcription (linguistics) , virology , viral replication , rna dependent rna polymerase , genetics , influenza a virus , translation (biology) , computational biology , gene , messenger rna , linguistics , philosophy

In one more years, we will 'celebrate' an exact centenary of the Spanish flu pandemic. With the rapid evolution of the influenza virus, the possibility of novel pandemic remains ever a concern. This review covers our current knowledge of the influenza A virus: on the role of RNA in translation, replication, what is known of the expressed proteins and the protein products generated from alternative splicing, and on the role of base pairing in RNA structure. We highlight the main events associated with viral entry into the cell, the transcription and replication process, an export of the viral genetic material from the nucleus and the final release of the virus. We discuss the observed potential roles of RNA secondary structure (the RNA base-pairing arrangement) and RNA/RNA interactions in this scheme.

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