Long noncoding RNAs in hematopoietic malignancies | Zendy

Norma I. Rodríguez-Malavé | Zendy; Dinesh S. Rao | Zendy

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Long noncoding RNAs in hematopoietic malignancies

Author(s) -

Norma I. Rodríguez-Malavé,

Dinesh S. Rao

Publication year - 2015

Publication title -

briefings in functional genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.22

H-Index - 67

eISSN - 2041-2647

pISSN - 2041-2649

DOI - 10.1093/bfgp/elv047

Subject(s) - biology , long non coding rna , small nucleolar rna , microrna , chromatin , rna splicing , computational biology , epigenetics , chromatin remodeling , regulation of gene expression , non coding rna , alternative splicing , rna , gene , genetics , messenger rna

Recent years have witnessed the discovery of several classes of noncoding RNAs (ncRNAs), which are indispensable for the regulation of cellular processes. Many of these RNAs are regulatory in nature with functions in gene expression regulation such as piwi-interacting RNAs, small interfering RNAs and micro RNAs. Long noncoding RNAs (lncRNAs) comprise the most recently characterized class. LncRNAs are involved in transcriptional regulation, chromatin remodeling, imprinting, splicing, and translation, among other critical functions in the cell. Recent studies have elucidated the importance of lncRNAs in hematopoietic development. Dysregulation of lncRNA expression is a feature of various diseases and cancers, and is also seen in hematopoietic malignancies. This article focuses on lncRNAs that have been implicated in the pathogenesis of hematopoietic malignancies.

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