Somatic structural variation and cancer | Zendy

José M. C. Tubío | Zendy

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Somatic structural variation and cancer

Author(s) -

José M. C. Tubío

Publication year - 2015

Publication title -

briefings in functional genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.22

H-Index - 67

eISSN - 2041-2647

pISSN - 2041-2649

DOI - 10.1093/bfgp/elv016

Subject(s) - biology , somatic cell , structural variation , genome , cancer , computational biology , carcinogenesis , genetics , evolutionary biology , variation (astronomy) , gene , physics , astrophysics

With the advent of next-generation sequencing technologies, we have witnessed a rapid pace of discovery of new patterns of somatic structural variation in cancer genomes, and an attempt to figure out their underlying mechanisms. Some of these mechanisms are associated with particular cancer types, and in some cases are the main cause of the structural mutations that drive the oncogenic process. This review provides an overview of the patterns of somatic structural variation and chromosomal structures that characterize cancer genomes, their causal mechanisms and their impact in oncogenesis.

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