In vivo formaldehyde cross-linking: it is time for black box analysis | Zendy

Alexey A. Gavrilov | Zendy; Sergey V. Razin | Zendy; Giacomo Cavalli | Zendy

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In vivo formaldehyde cross-linking: it is time for black box analysis

Author(s) -

Alexey A. Gavrilov,

Sergey V. Razin,

Giacomo Cavalli

Publication year - 2014

Publication title -

briefings in functional genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.22

H-Index - 67

eISSN - 2041-2647

pISSN - 2041-2649

DOI - 10.1093/bfgp/elu037

Subject(s) - biology , chromatin , formaldehyde , in vivo , black box , chromosome , chromatin immunoprecipitation , computational biology , immunoprecipitation , genetics , component (thermodynamics) , evolutionary biology , dna , gene , biochemistry , computer science , gene expression , promoter , artificial intelligence , physics , thermodynamics

Formaldehyde cross-linking is an important component of many technologies, including chromatin immunoprecipitation and chromosome conformation capture. The procedure remains empirical and poorly characterized, however, despite a long history of its use in research. Little is known about the specificity of in vivo cross-linking, its efficiency and chemical adducts induced by the procedure. It is time to search this black box.

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