Gene transcription in the zebrafish embryo: regulators and networks | Zendy

Marco Ferg | Zendy; Olivier Armant | Zendy; Lixin Yang | Zendy; Thomas Dickmeis | Zendy; Sepand Rastegar | Zendy; Uwe Strähle | Zendy

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Gene transcription in the zebrafish embryo: regulators and networks

Author(s) -

Marco Ferg,

Olivier Armant,

Lixin Yang,

Thomas Dickmeis,

Sepand Rastegar,

Uwe Strähle

Publication year - 2013

Publication title -

briefings in functional genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.22

H-Index - 67

eISSN - 2041-2647

pISSN - 2041-2649

DOI - 10.1093/bfgp/elt044

Subject(s) - biology , zebrafish , gene , gene regulatory network , regulation of gene expression , genetics , computational biology , encode , gene expression , transcription factor , genome , vertebrate , cis regulatory module , transcription (linguistics) , promoter , linguistics , philosophy

The precise spatial and temporal control of gene expression is a key process in the development, maintenance and regeneration of the vertebrate body. A substantial proportion of vertebrate genomes encode genes that control the transcription of the genetic information into mRNA. The zebrafish is particularly well suited to investigate gene regulatory networks underlying the control of gene expression during development due to the external development of its transparent embryos and the increasingly sophisticated tools for genetic manipulation available for this model system. We review here recent data on the analysis of cis-regulatory modules, transcriptional regulators and their integration into gene regulatory networks in the zebrafish, using the developing spinal cord as example.

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