Dynamics of the DNA damage response: insights from live-cell imaging | Zendy

Ketki Karanam | Zendy; Alexander Loewer | Zendy; Galit Lahav | Zendy

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Dynamics of the DNA damage response: insights from live-cell imaging

Author(s) -

Ketki Karanam,

Alexander Loewer,

Galit Lahav

Publication year - 2013

Publication title -

briefings in functional genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.22

H-Index - 67

eISSN - 2041-2647

pISSN - 2041-2649

DOI - 10.1093/bfgp/els059

Subject(s) - biology , live cell imaging , dna damage , dna , genome , microbiology and biotechnology , cell , dna repair , computational biology , genome instability , genetics , gene

All organisms have to safeguard the integrity of their genome to prevent malfunctioning and oncogenic transformation. Sophisticated DNA damage response mechanisms have evolved to detect and repair genomic lesions. With the emergence of live-cell microscopy of individual cells, we now begin to appreciate the complex spatiotemporal kinetics of the DNA damage response and can address the causes and consequences of the heterogeneity in the responses of genetically identical cells. Here, we highlight key discoveries where live-cell imaging has provided unprecedented insights into how cells respond to DNA double-strand breaks and discuss the main challenges and promises in using this technique.

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