Biological function through network topology: a survey of the human diseasome | Zendy

Vuk Janjić | Zendy; Nataša Pržulj | Zendy

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Biological function through network topology: a survey of the human diseasome

Author(s) -

Vuk Janjić,

Nataša Pržulj

Publication year - 2012

Publication title -

briefings in functional genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.22

H-Index - 67

eISSN - 2041-2647

pISSN - 2041-2649

DOI - 10.1093/bfgp/els037

Subject(s) - biology , biological network , field (mathematics) , function (biology) , multitude , computational biology , systems biology , data science , human disease , computer science , evolutionary biology , genetics , mathematics , epistemology , gene , pure mathematics , philosophy

Molecular network data are increasingly becoming available, necessitating the development of well performing computational tools for their analyses. Such tools enabled conceptually different approaches for exploring human diseases to be undertaken, in particular, those that study the relationship between a multitude of biomolecules within a cell. Hence, a new field of network biology has emerged as part of systems biology, aiming to untangle the complexity of cellular network organization. We survey current network analysis methods that aim to give insight into human disease.

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