In vitro methods for peptide display and their applications | Zendy

Christopher G. Ullman | Zendy; Laura Frigotto | Zendy; Rachel Cooley | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

In vitro methods for peptide display and their applications

Author(s) -

Christopher G. Ullman,

Laura Frigotto,

Rachel Cooley

Publication year - 2011

Publication title -

briefings in functional genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.22

H-Index - 67

eISSN - 2041-2647

pISSN - 2041-2649

DOI - 10.1093/bfgp/elr010

Subject(s) - phage display , peptide , biology , peptide library , computational biology , directed molecular evolution , recombinant dna , peptide sequence , biochemistry , directed evolution , gene , mutant

The presentation of recombinant peptide libraries linked to their coding sequence can be referred to as 'peptide display'. Phage display is the most widely practiced peptide display technology but more recent alternatives such as CIS display, ribosome display and mRNA display offer advantages over phage for speed, library size and the display of unnatural amino acids. These have provided researchers with tools to address some of the failings of peptides such as their low affinity, low stability and inability to cross biological membranes. In this review, we assess some of the recent advances in peptide display and its application.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research