Genotypic analysis of gene expression in the dissection of the aetiology of complex neurological and psychiatric diseases | Zendy

Mina Ryten | Zendy; Daniah Trabzuni | Zendy; John Hardy | Zendy

Open Access

Genotypic analysis of gene expression in the dissection of the aetiology of complex neurological and psychiatric diseases

Author(s) -

Mina Ryten,

Daniah Trabzuni,

John Hardy

Publication year - 2009

Publication title -

briefings in functional genomics and proteomics

Language(s) - English

Resource type - Journals

eISSN - 1477-4062

pISSN - 1473-9550

DOI - 10.1093/bfgp/elp028

Subject(s) - biology , genotype , gene , disease , genetics , open reading frame , gene expression , etiology , genetic variability , bioinformatics , psychiatry , pathology , psychology , medicine , peptide sequence

Over the last year, many reliable genetic associations with complex diseases have been reported including some associations with complex neurological and psychiatric diseases. Many of these disease associations do not map to coding changes in protein open reading frames, but rather are believed to lead to genetic variability in gene expression and splicing. Such effects can be dissected by studies, which use genetic variability in mRNA expression as quantitative traits and regress these traits against genotype.

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