The neurogenetic frontier--lessons from misbehaving zebrafish | Zendy

Harold A. Burgess | Zendy; Michael Granato | Zendy

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The neurogenetic frontier--lessons from misbehaving zebrafish

Author(s) -

Harold A. Burgess,

Michael Granato

Publication year - 2008

Publication title -

briefings in functional genomics and proteomics

Language(s) - English

Resource type - Journals

eISSN - 1477-4062

pISSN - 1473-9550

DOI - 10.1093/bfgp/eln039

Subject(s) - zebrafish , neuroscience , biology , forward genetics , function (biology) , model organism , genetic screen , biological neural network , neuronal circuits , mutagenesis , brain function , process (computing) , component (thermodynamics) , computational biology , cognitive science , mutation , psychology , computer science , mutant , genetics , gene , thermodynamics , physics , operating system

One of the central questions in neuroscience is how refined patterns of connectivity in the brain generate and monitor behavior. Genetic mutations can influence neural circuits by disrupting differentiation or maintenance of component neuronal cells or by altering functional patterns of nervous system connectivity. Mutagenesis screens therefore have the potential to reveal not only the molecular underpinnings of brain development and function, but to illuminate the cellular basis of behavior. Practical considerations make the zebrafish an organism of choice for undertaking forward genetic analysis of behavior. The powerful array of experimental tools at the disposal of the zebrafish researcher makes it possible to link molecular function to neuronal properties that underlie behavior. This review focuses on specific challenges to isolating and analyzing behavioral mutants in zebrafish.

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