Open AccessMulti-protein complexes at the -globin locus
Author(s) -
Milind Mahajan
Publication year - 2006
Publication title -
briefings in functional genomics and proteomics
Language(s) - English
Resource type - Journals
eISSN - 1477-4062
pISSN - 1473-9550
DOI - 10.1093/bfgp/ell001
Subject(s) - biology , locus (genetics) , locus control region , gene , globin , promoter , genetics , computational biology , gene expression
Biochemical analysis of the beta-globin gene function has led to the identification of several multi-protein complexes at the locus control region (LCR), insulator and promoters. This review briefly summarizes these multi-protein complexes and discusses their contribution towards the regulation of the beta-globin gene expression.
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