Use of transgenic zebrafish reporter lines to study calcium signalling in development | Zendy

Rachel Ashworth | Zendy

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Use of transgenic zebrafish reporter lines to study calcium signalling in development

Author(s) -

Rachel Ashworth

Publication year - 2005

Publication title -

briefings in functional genomics and proteomics

Language(s) - English

Resource type - Journals

eISSN - 1477-4062

pISSN - 1473-9550

DOI - 10.1093/bfgp/4.2.186

Subject(s) - zebrafish , biology , calcium , transgene , calcium signaling , microbiology and biotechnology , signalling , calcium imaging , calcium binding protein , computational biology , signal transduction , genetics , gene , medicine

Calcium signals are associated with many of the events common to animal development. Understanding the role of these calcium signals requires the ability to visualise and manipulate calcium levels in the developing embryo. Recent work has led to the development of sensitive protein-based probes that can be used to generate transgenic animals for the analysis of calcium signalling in vivo. This paper focuses on the use of genetically encoded calcium probes to follow calcium signals in zebrafish. It reviews progress and speculates on the potential for use in the future.

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