DNA methylation, nucleosome formation and positioning | Zendy

Sari Pennings | Zendy; James M. Allan | Zendy; Colin Davey | Zendy

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DNA methylation, nucleosome formation and positioning

Author(s) -

Sari Pennings,

James M. Allan,

Colin Davey

Publication year - 2005

Publication title -

briefings in functional genomics and proteomics

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1477-4062

pISSN - 1473-9550

DOI - 10.1093/bfgp/3.4.351

Subject(s) - nucleosome , biology , histone octamer , dna methylation , histone methylation , chromatin , genetics , epigenetics , histone , chromatosome , epigenomics , linker dna , solenoid , dna , computational biology , microbiology and biotechnology , gene , gene expression , physics , quantum mechanics

Recent mapping of nucleosome positioning on several long gene regions subject to DNA methylation has identified instances of nucleosome repositioning by this base modification. The evidence for an effect of CpG methylation on nucleosome formation and positioning in chromatin is reviewed here in the context of the complex sequence-structure requirements of DNA wrapping around the histone octamer and the role of this epigenetic mark in gene repression.

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