Chromatin higher order structure: Opening up chromatin for transcription | Zendy

Attila Németh | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Chromatin higher order structure: Opening up chromatin for transcription

Author(s) -

Attila Németh

Publication year - 2004

Publication title -

briefings in functional genomics and proteomics

Language(s) - English

Resource type - Journals

eISSN - 1477-4062

pISSN - 1473-9550

DOI - 10.1093/bfgp/2.4.334

Subject(s) - chromatin , biology , microbiology and biotechnology , histone modifying enzymes , chip sequencing , histone , dna , scaffold/matrix attachment region , transcription (linguistics) , chia pet , chromatin remodeling , biophysics , genetics , linguistics , philosophy

DNA packaged into chromatin is the physiologically relevant substrate for all DNA-dependent processes inside the nuclei of eukaryotic cells. The highly compacted structures of DNA and histones is inherently repressive for all DNA-dependent processes. Active mechanisms exist to generate dynamic chromatin, which maintains two apparently contradictory functions: tight compaction and free accessibility of DNA. The dynamics of chromatin higher order folding and the influence of chromatin structure on transcription will be described in this paper. Chromatin dynamics and higher order folding may be the key regulators of not only transcription but of all DNA-dependent processes in the nucleus.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research