Application of proteomics for discovery of protein biomarkers | Zendy

E. John Hale | Zendy; Valentina Gelfanova | Zendy; R. James Ludwig | Zendy; Michael D. Knierman | Zendy

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Application of proteomics for discovery of protein biomarkers

Author(s) -

E. John Hale,

Valentina Gelfanova,

R. James Ludwig,

Michael D. Knierman

Publication year - 2003

Publication title -

briefings in functional genomics and proteomics

Language(s) - English

Resource type - Journals

eISSN - 1477-4062

pISSN - 1473-9550

DOI - 10.1093/bfgp/2.3.185

Subject(s) - biomarker discovery , drug discovery , biology , proteomics , computational biology , strengths and weaknesses , key (lock) , data science , biomarker , drug development , bioinformatics , computer science , drug , pharmacology , biochemistry , ecology , philosophy , epistemology , gene

Biomarkers of drug efficacy and toxicity are becoming a key need in the drug development process. Mass spectral-based proteomic technologies are ideally suited for the discovery of protein biomarkers in the absence of any prior knowledge of quantitative changes in protein levels. The success of any biomarker discovery effort will depend upon the quality of samples analysed, the ability to generate quantitative information on relative protein levels and the ability to readily interpret the data generated. This review will focus on the strengths and weaknesses of technologies currently utilised to address these issues.

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