DUSP4 promotes the carcinogenesis of CCRCC via negative regulation of autophagic death | Zendy

Xianyou Zeng | Zendy; Changyan Zhu | Zendy; Xianxin Zhu | Zendy

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DUSP4 promotes the carcinogenesis of CCRCC via negative regulation of autophagic death

Author(s) -

Xianyou Zeng,

Changyan Zhu,

Xianxin Zhu

Publication year - 2021

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1093/bbb/zbab111

Subject(s) - gene silencing , autophagy , carcinogenesis , clear cell renal cell carcinoma , programmed cell death , cancer research , downregulation and upregulation , cell growth , cell , microbiology and biotechnology , biology , chemistry , renal cell carcinoma , medicine , apoptosis , gene , biochemistry

DUSP4 is considered as an oncogenic gene. However, the effect of DUSP4 on the carcinogenesis of clear cell Renal cell carcinoma (CCRCC) is still unclear. In this study, DUSP4 mRNA levels were significantly increased in CCRCC tissues and cell lines. Furthermore, DUSP4 overexpression promotes the proliferation, migration, and tumorigenicity of CCRCC cells while DUSP4 silencing showed the opposite effects. Importantly, both autophagic activity (LC3 conversion rate and LC3 puncta formation) and total death level promoted by DUSP4 silencing were reversed by treatment with 3-MA in CCRCC cells. Moreover, the proliferation and migration of CCRCC cells inhibited by DUSP4 silencing were also recovered by suppression of autophagy with 3-MA. In conclusion, DUSP4 serves as an oncogenic gene in CCRCC carcinogenesis due to its inhibitory effect on autophagic death, indicating the potential value of DUSP4 in the diagnosis and treatment of CCRCC.

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