A new peptaibol, RK-026A, from the soil fungusTrichodermasp. RK10-F026 by culture condition-dependent screening | Zendy

Mira Syahfriena Amir Rawa | Zendy; Toshihiko Nogawa | Zendy; Akiko Okano | Zendy; Yushi Futamura | Zendy; Takemichi Nakamura | Zendy; Habibah A. Wahab | Zendy; Hiroyuki Osada | Zendy

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A new peptaibol, RK-026A, from the soil fungusTrichodermasp. RK10-F026 by culture condition-dependent screening

Author(s) -

Mira Syahfriena Amir Rawa,

Toshihiko Nogawa,

Akiko Okano,

Yushi Futamura,

Takemichi Nakamura,

Habibah A. Wahab,

Hiroyuki Osada

Publication year - 2021

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1093/bbb/zbaa051

Subject(s) - alamethicin , fungus , cytotoxicity , stereochemistry , trichoderma , residue (chemistry) , chemistry , biology , botany , biochemistry , in vitro , membrane , lipid bilayer

A new peptaibol, RK-026A (1) was isolated from a fungus, Trichoderma sp. RK10-F026, along with atroviridin B (2), alamethicin II (3), and polysporin B (4) as a cytotoxic compound, which was selected by principal component analysis of the MS data from 5 different culture conditions. The structure of 1 was determined as a new atroviridin B derivative containing Glu at the 18th residue instead of Gln by NMR and HR-MS analyses including the investigation of detailed MS/MS fragmentations. 1 showed cytotoxicity toward K562 leukemia cells at an IC50 value of 4.1 µm.

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