Liver choline metabolism and gene expression in choline-deficient mice offspring differ with gender | Zendy

Yukino Miyachi | Zendy; Kei Akiyama | Zendy; Y. Tsukuda | Zendy; Thanutchaporn Kumrungsee | Zendy; Noriyuki Yanaka | Zendy

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Liver choline metabolism and gene expression in choline-deficient mice offspring differ with gender

Author(s) -

Yukino Miyachi,

Kei Akiyama,

Y. Tsukuda,

Thanutchaporn Kumrungsee,

Noriyuki Yanaka

Publication year - 2021

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1093/bbb/zbaa047

Subject(s) - offspring , choline , betaine , endocrinology , medicine , biology , lactation , pregnancy , gene expression , metabolism , gene , biochemistry , genetics

Choline is an important nutrient during pregnancy and lactation. Maternal choline deficiency in CD-1 mice lowers liver betaine levels in male offspring. By contrast, it increases elovl3 and vanin-1 mRNA levels in female offspring. Taken together, these observations suggest gender-specific responses to a choline-deficient diet.

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