SQAP, an acyl sulfoquinovosyl derivative, suppresses expression of histone deacetylase and induces cell death of cancer cells under hypoxic conditions | Zendy

Hirofumi Kawakubo | Zendy; Shinji Kamisuki | Zendy; Kei Suzuki | Zendy; Jesus Izaguirre-Carbonell | Zendy; Shiki Saito | Zendy; Hiroshi Murata | Zendy; Atsushi Tanabe | Zendy; Ayumi Hongo | Zendy; Hironobu Murakami | Zendy; Sachihiro Matsunaga | Zendy; Kengo Sakaguchi | Zendy; Hiroeki Sahara | Zendy; Fumio Sugawara | Zendy; Kouji Kuramochi | Zendy

Open Access

SQAP, an acyl sulfoquinovosyl derivative, suppresses expression of histone deacetylase and induces cell death of cancer cells under hypoxic conditions

Author(s) -

Hirofumi Kawakubo,

Shinji Kamisuki,

Kei Suzuki,

Jesus Izaguirre-Carbonell,

Shiki Saito,

Hiroshi Murata,

Atsushi Tanabe,

Ayumi Hongo,

Hironobu Murakami,

Sachihiro Matsunaga,

Kengo Sakaguchi,

Hiroeki Sahara,

Fumio Sugawara,

Kouji Kuramochi

Publication year - 2021

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1093/bbb/zbaa015

Subject(s) - histone deacetylase , acetylation , hdac1 , hypoxia (environmental) , chemistry , cancer cell , histone , histone deacetylase 2 , histone deacetylase 5 , cell , hypoxia inducible factors , hdac10 , histone deacetylase inhibitor , cancer research , histone acetyltransferase , biochemistry , biology , cancer , oxygen , genetics , organic chemistry , gene

Sulfoglycolipid, SQAP, is a radiosensitizing agent that makes tumor cells more sensitive to radiation therapy. A previous study revealed that SQAP induced the degradation of hypoxia-inducible factor-1α (HIF-1α) and inhibited angiogenesis in a hepatoma model mouse. Herein, we examined the biological activities of SQAP against hepatocarcinoma cells under low oxygen conditions. Cell growth inhibition of SQAP under hypoxic conditions was significantly higher than that under normoxic conditions. In addition, SQAP was found to impair the expression of histone deacetylase (HDAC) under low oxygen conditions. Our present data suggested that SQAP induced the degradation of HIF-1α and then decreased the expression of HDAC1. Unlike known HDAC inhibitors, SQAP increased the acetylation level of histone in cells without inhibition of enzymatic activity of HDACs. Our data demonstrated hypoxia-specific unique properties of SQAP.

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