English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Background Polymethylmethacrylate (PMMA)-collagen gel is approved for the correction of nasolabial folds and severe atrophic, distensible facial acne scars on the cheek. However, fillers are often used off-label in clinical practice, necessitating additional study of safety and efficacy. Objective To determine the safety and efficacy of PMMA-collagen gel for the correction of lower face aging, specifically the pre-jowl sulcus. Methods In this prospective, single-center, 1-year study (N=20) and additional 1-year extension (N=10), 20 subjects with a pre-treatment score of 2, 3, or 4 on the 5-point Merz Aesthetic Scale for jawline at rest were eligible for treatment with PMMA-collagen gel. Efficacy was measured by blinded review using the jawline scale. Subject and Physician Global Aesthetic Improvement Scale (GAIS) and Subject Satisfaction scores were collected at weeks 4, 12, 26, 52, and 104. Results Improvement in jawline score was significant at all post-treatment time points up to 104 weeks (P&amp;lt;0.05). The percentage of subjects with SGAIS ratings of “improved” or “much improved” was 79% at 12 weeks. Ratings were maintained at 76% at 52 weeks and increased to 90% at week 104. At 52 and 104 weeks, 82% and 100% of subjects, respectively, were at least “somewhat satisfied.” All adverse events were minor. Conclusions PMMA-collagen gel is well tolerated and effective for durable correction of the pre-jowl sulcus and jawline.

Safety and Efficacy of Polymethylmethacrylate-Collagen Gel Filler for Correction of the Pre-jowl Sulcus: A 24-month Prospective Study