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Hyaluronic acid (HA) fillers are sometimes mixed with lidocaine to mitigate pain. Whether the addition of epinephrine to lidocaine provides greater benefits in bruising and pain has not been fully reported.

aesthetic surgery journal

A Blinded, Randomized, Split-Face Pilot Study of Bruising and Pain With Hyaluronic Acid for Correction of Perioral Lines Using No Lidocaine, Lidocaine Alone, and Lidocaine and Epinephrine