Attention Measures of Accuracy, Variability, and Fatigue Detect Early Response to Donepezil in Alzheimer’s Disease: A Randomized, Double-blind, Placebo-Controlled Pilot Trial | Zendy

Clara VilaCastelar | Zendy; Jenny Ly | Zendy; Lillian Kaplan | Zendy; Kathleen Van Dyk | Zendy; Jeffrey T. Berger | Zendy; Lucy O. Macina | Zendy; Jennifer L. Stewart | Zendy; Nancy S. Foldi | Zendy

Open Access

Attention Measures of Accuracy, Variability, and Fatigue Detect Early Response to Donepezil in Alzheimer’s Disease: A Randomized, Double-blind, Placebo-Controlled Pilot Trial

Author(s) -

Clara VilaCastelar,

Jenny Ly,

Lillian Kaplan,

Kathleen Van Dyk,

Jeffrey T. Berger,

Lucy O. Macina,

Jennifer L. Stewart,

Nancy S. Foldi

Publication year - 2018

Publication title -

archives of clinical neuropsychology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.909

H-Index - 98

eISSN - 1873-5843

pISSN - 0887-6177

DOI - 10.1093/arclin/acy032

Subject(s) - donepezil , psychology , placebo , cognition , randomized controlled trial , audiology , dementia , rating scale , memory span , alzheimer's disease , physical medicine and rehabilitation , medicine , psychiatry , working memory , developmental psychology , disease , alternative medicine , pathology

Donepezil is widely used to treat Alzheimer's disease (AD), but detecting early response remains challenging for clinicians. Acetylcholine is known to directly modulate attention, particularly under high cognitive conditions, but no studies to date test whether measures of attention under high load can detect early effects of donepezil. We hypothesized that load-dependent attention tasks are sensitive to short-term treatment effects of donepezil, while global and other domain-specific cognitive measures are not.

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