Open AccessApolipoprotein E ɛ4, Cognitive Function, and Pain Experience in Down Syndrome: A Pilot Study
Author(s) -
Nanda C. de Knegt,
Carlo Schuengel,
Heleen M. Evenhuis,
Frank Lobbezoo,
Erik Scherder
Publication year - 2016
Publication title -
archives of clinical neuropsychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 98
eISSN - 1873-5843
pISSN - 0887-6177
DOI - 10.1093/arclin/acw022
Subject(s) - apolipoprotein e , cognition , neuropsychology , psychology , clinical psychology , chronic pain , coping (psychology) , medicine , psychiatry , disease
The presence of apolipoprotein E (ApoE) ɛ4 allele might be related to higher pain experience due to increased risk for potentially painful physical conditions and cognitive impairment (less efficient coping with pain). This hypothesis is clinically relevant to examine in adults with Down syndrome (DS) because they are at risk for painful physical conditions, their presence of ApoE ε4 is related to cognitive impairment, and their pain experience is unclear. The present pilot study addressed the associations between ApoE genotype, cognition, and pain in DS.
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