Open AccessPre-Surgical Mood Predicts Memory Decline after Anterior Temporal Lobe Resection for Epilepsy
Author(s) -
Robyn M. Busch,
Mario F. Dulay,
Kevin H. Kim,
Jessica S. Chapin,
Lara Jehi,
Colleen C. Kalman,
Richard I. Naugle,
Imad Najm
Publication year - 2011
Publication title -
archives of clinical neuropsychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 98
eISSN - 1873-5843
pISSN - 0887-6177
DOI - 10.1093/arclin/acr067
Subject(s) - mood , wechsler memory scale , cognitive decline , beck depression inventory , psychology , verbal memory , temporal lobe , depression (economics) , cognition , epilepsy surgery , anterior temporal lobectomy , epilepsy , psychiatry , wechsler adult intelligence scale , medicine , anxiety , dementia , disease , economics , macroeconomics
This study examined pre-surgical depressed mood as a predictor of post-surgical memory change in adults who underwent temporal lobe resections (TLRs; n = 211). Patients completed the Wechsler Memory Scale-III and Beck Depression Inventory-Second Edition (BDI-II) before and after TLR (left = 110, right = 101) and were divided into two groups (clinically elevated depressive symptoms or not depressed) based on BDI-II score. Left-TLR patients with poorer pre-surgical mood had greater verbal memory declines after surgery compared with nondepressed left- or right-TLR patients and right-TLR patients with poor mood. Further, pre-surgical BDI-II score demonstrated incremental validity in predicting post-surgical memory change in left-TLR patients beyond pre-surgical memory scores. Differences in seizure outcome and post-surgical mood change could not account for memory decline. Results suggest that elevated pre-surgical depressive symptomatology is a risk factor for post-surgical memory decline and indicate that mood should be considered when advising patients about cognitive risks associated with temporal lobectomy. Results are discussed in terms of poor pre-surgical mood as an indicator of reduced cognitive reserve.