DNA replication stress induces deregulation of the cell cycle events in root meristems of Allium cepa | Zendy

Aneta Żabka | Zendy; Justyna Teresa Polit | Zendy; Janusz Maszewski | Zendy

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DNA replication stress induces deregulation of the cell cycle events in root meristems of Allium cepa

Author(s) -

Aneta Żabka,

Justyna Teresa Polit,

Janusz Maszewski

Publication year - 2012

Publication title -

annals of botany

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.567

H-Index - 176

eISSN - 1095-8290

pISSN - 0305-7364

DOI - 10.1093/aob/mcs215

Subject(s) - biology , chromatin , premature chromosome condensation , mitosis , microbiology and biotechnology , interphase , cell cycle , histone , dapi , dna replication , cell , dna , biochemistry , genetics , staining

Prolonged treatment of Allium cepa root meristems with changing concentrations of hydroxyurea (HU) results in either premature chromosome condensation or cell nuclei with an uncommon form of biphasic chromatin organization. The aim of the current study was to assess conditions that compromise cell cycle checkpoints and convert DNA replication stress into an abnormal course of mitosis.

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