Open AccessCharacterization of Endotoxin and Mouse Allergen Exposures in Mouse Facilities and Research Laboratories
Author(s) -
Karin Pacheco,
Charles Mccammon,
Peter S. Thorne,
Marsha E. O'Neill,
Andrew H. Liu,
John W. Martyny,
M. VanDyke,
Lee S. Newman,
Cecile S. Rose
Publication year - 2006
Publication title -
the annals of occupational hygiene
Language(s) - English
Resource type - Journals
eISSN - 1475-3162
pISSN - 0003-4878
DOI - 10.1093/annhyg/mel019
Subject(s) - allergen , sensitization , airborne allergen , immunology , inhalation exposure , toxicology , veterinary medicine , medicine , allergy , biology , toxicity
Researchers and technicians who use mice in research are exposed to complex mixtures containing mouse allergen, endotoxin and particulates from animals, bedding and feed. The particle characteristics of these different exposures, and whether they are encountered together or separately, are important to better understand their adjuvant and allergic effects. Endotoxin and mouse allergen are derived from the same animal source, but have different physicochemical attributes. It is not known if airborne exposures to these agents are correlated in the laboratory animal workplace.
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