Selective Blockade of T-Type Ca2+ Channels is Protective Against Alcohol-Withdrawal Induced Seizure and Mortality | Zendy

Melissa L. Masicampo | Zendy; Hong Qu Shan | Zendy; Victoria Xu | Zendy; Merritt Speagle | Zendy; Dwayne W. Godwin | Zendy

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Selective Blockade of T-Type Ca2+ Channels is Protective Against Alcohol-Withdrawal Induced Seizure and Mortality

Author(s) -

Melissa L. Masicampo,

Hong Qu Shan,

Victoria Xu,

Merritt Speagle,

Dwayne W. Godwin

Publication year - 2018

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agy042

Subject(s) - blockade , antagonist , ethosuximide , pharmacology , calcium channel , alcohol , ethanol , convulsion , voltage dependent calcium channel , calcium , anesthesia , medicine , chemistry , anticonvulsant , epilepsy , receptor , biochemistry , psychiatry

We have previously demonstrated that blockade of T-type calcium channels by the non-selective antagonist, ethosuximide (ETX), is effective at reducing electrographical and behavioral correlates of alcohol-withdrawal (WD) seizure. Here, we investigated whether blockade of these calcium channels with the selective antagonist TTA-P2 also reduces alcohol-WD seizure.

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