PNPLA3 Association with Alcoholic Liver Disease in a Cohort of Heavy Drinkers | Zendy

Bhanu Prakash Kolla | Zendy; Terry D. Schneekloth | Zendy; Joanna M. Biernacka | Zendy; Vijay H. Shah | Zendy; Konstantinos N. Lazaridis | Zendy; Jennifer R. Geske | Zendy; Victor M. Karpyak | Zendy

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PNPLA3 Association with Alcoholic Liver Disease in a Cohort of Heavy Drinkers

Author(s) -

Bhanu Prakash Kolla,

Terry D. Schneekloth,

Joanna M. Biernacka,

Vijay H. Shah,

Konstantinos N. Lazaridis,

Jennifer R. Geske,

Victor M. Karpyak

Publication year - 2018

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agy007

Subject(s) - single nucleotide polymorphism , bonferroni correction , medicine , cohort , logistic regression , snp , body mass index , case control study , odds ratio , genotype , genetics , biology , gene , statistics , mathematics

Prior studies have established variation at the PNPLA3 gene to be associated with a risk of developing alcoholic liver disease (ALD). We attempt to replicate this finding and other potential genetic variations previously associated with ALD utilizing a case-control design in a cohort of subjects with alcohol use disorders.

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