Joint Effects of the Epigenetic Alteration of Neurotrophins and Cytokine Signaling: A Possible Exploratory Model of Affective Symptoms in Alcohol-Dependent Patients? | Zendy

Annemarie Heberlein | Zendy; R. Schuster | Zendy; Alexandra Kleimann | Zendy; Adrian Groh | Zendy; Andreas Kordon | Zendy; Birgitt Opfermann | Zendy; Ralf Lichtinghagen | Zendy; Michael Gröschl | Zendy; Johannes Kornhuber | Zendy; Stefan Bleich | Zendy; Helge Frieling | Zendy; Thomas Hillemacher | Zendy

Open Access

Joint Effects of the Epigenetic Alteration of Neurotrophins and Cytokine Signaling: A Possible Exploratory Model of Affective Symptoms in Alcohol-Dependent Patients?

Author(s) -

Annemarie Heberlein,

R. Schuster,

Alexandra Kleimann,

Adrian Groh,

Andreas Kordon,

Birgitt Opfermann,

Ralf Lichtinghagen,

Michael Gröschl,

Johannes Kornhuber,

Stefan Bleich,

Helge Frieling,

Thomas Hillemacher

Publication year - 2016

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agw100

Subject(s) - methylation , epigenetics , cytokine , neurotrophic factors , neurotrophin , tumor necrosis factor alpha , interleukin 6 , medicine , psychology , endocrinology , brain derived neurotrophic factor , receptor , biology , gene , genetics

Neurotrophins have been linked to the symptomatology of alcohol dependence. We aimed to investigate a possible association between the methylation of the promoters of both neurotrophins, the serum levels of the cytokines and core symptoms of alcohol dependence as withdrawal severity and anxiety.

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