Ethosuximide Reduces Mortality and Seizure Severity in Response to Pentylenetetrazole Treatment During Ethanol Withdrawal | Zendy

Melissa A. Riegle | Zendy; Melissa L. Masicampo | Zendy; Hong Shan | Zendy; Victoria Xu | Zendy; Dwayne W. Godwin | Zendy

Open Access

Ethosuximide Reduces Mortality and Seizure Severity in Response to Pentylenetetrazole Treatment During Ethanol Withdrawal

Author(s) -

Melissa A. Riegle,

Melissa L. Masicampo,

Hong Shan,

Victoria Xu,

Dwayne W. Godwin

Publication year - 2015

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agv033

Subject(s) - ethosuximide , ethanol , medicine , kindling , anesthesia , pharmacology , epilepsy , anticonvulsant , alcohol , chemistry , psychiatry , biochemistry

We recently demonstrated that T-type calcium channels are affected by alcohol abuse and withdrawal. Treatment with ethosuximide, an antiepileptic drug that blocks T-type calcium channels, reduces seizure activity induced by intermittent ethanol exposures and withdrawals. Here, we expand on these findings to test whether ethosuximide can reduce the sensitivity to pentylenetetrazole-induced seizures during ethanol withdrawal.

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