A Pharmaco-EEG-Based Assessment of the Interaction Between Ethanol and Zonisamide
Author(s) -
Bogusława Pietrzak,
Ewa Zwierzyńska,
Agata Krupa
Publication year - 2014
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/agu024
Subject(s) - zonisamide , hippocampus , ethanol , midbrain reticular formation , anticonvulsant , pharmacology , anesthesia , chemistry , medicine , psychology , central nervous system , epilepsy , midbrain , neuroscience , biochemistry , topiramate
Recent research suggests a potential role for a new generation of anticonvulsant drugs, including zonisamide, in the treatment of alcohol dependence. Some elements of the central mechanism of action that zonisamide has in common with ethanol, give rise to the question of whether there is an interaction between these two agents and whether there is any risk associated with the enhanced depressive effect of these agents on the central nervous system.
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