Neuronal Nitric Oxide Synthase Mediates the Effect of Ethanol on IgA | Zendy

Mirela Budeč | Zendy; Dragana Marković | Zendy; Sanja Vignjević | Zendy; Olivera Mitrović Ajtić | Zendy; Dragoslava Đikić | Zendy; Vesna Koko | Zendy; Vladan P. Čokić | Zendy

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Neuronal Nitric Oxide Synthase Mediates the Effect of Ethanol on IgA

Author(s) -

Mirela Budeč,

Dragana Marković,

Sanja Vignjević,

Olivera Mitrović Ajtić,

Dragoslava Đikić,

Vesna Koko,

Vladan P. Čokić

Publication year - 2012

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/ags110

Subject(s) - nitric oxide synthase , western blot , ethanol , nitric oxide , medicine , endocrinology , chemistry , lamina propria , immunoglobulin a , saline , enzyme , immunohistochemistry , small intestine , alcohol , antibody , biochemistry , immunology , biology , immunoglobulin g , pathology , epithelium , gene

We showed previously that the acute effect of ethanol on intestinal immunoglobulin A (IgA) expression might be mediated by endogenous nitric oxide (NO). To extend these findings, this study was designed to investigate a possible role of neuronal NO synthase (nNOS) in the observed phenomenon, using 7-nitroindazole (7-NI), a selective inhibitor of its activity.

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