Open AccessCardiovascular Responses and Differential Changes in Mitogen-Activated Protein Kinases Following Repeated Episodes of Binge Drinking
Author(s) -
Lianzhi Gu,
Anne M. Fink,
Shamim Chowdhury,
David L. Geenen,
Mariann R. Piano
Publication year - 2012
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/ags090
Subject(s) - binge drinking , carvedilol , medicine , endocrinology , kinase , chemistry , poison control , heart failure , biochemistry , medical emergency , suicide prevention
Excessive alcohol use in the form of binge drinking is associated with many adverse medical outcomes. Using an animal model, the primary objective of this study was to determine the effects of repeated episodes of binge drinking on myocardial structure, blood pressure (BP) and activation of mitogen-activated protein kinases (MAPKs). The effects of carvedilol, a beta-adrenergic blocker, were also examined in this animal model of binge drinking.
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