Activation of Liver Tryptophan Pyrrolase Mediates the Decrease in Tryptophan Availability to the Brain after Acute Alcohol Consumption by Normal Subjects | Zendy

A. A-B Badawy | Zendy; D. M. Doughrty | Zendy; Dawn M. MarshRichard | Zendy; Andrew Steptoe | Zendy

Open Access

Activation of Liver Tryptophan Pyrrolase Mediates the Decrease in Tryptophan Availability to the Brain after Acute Alcohol Consumption by Normal Subjects

Author(s) -

A. A-B Badawy,

D. M. Doughrty,

Dawn M. MarshRichard,

Andrew Steptoe

Publication year - 2009

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agp005

Subject(s) - kynurenine , tryptophan , kynurenine pathway , chemistry , medicine , endocrinology , ethanol , alcohol , enzyme , biochemistry , amino acid

We have previously suggested that acute ethanol consumption by normal subjects decreases the availability of circulating tryptophan (Trp) to the brain by activating liver Trp pyrrolase, the first and rate-limiting enzyme of the (major) kynurenine pathway of Trp degradation. The aim of the present study was to examine this hypothesis further by measuring plasma levels of kynurenine metabolites following alcohol consumption.

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