Alcohol exposure alters cell cycle and apoptotic events during early neurulation | Zendy

Benjamin Anthony | Zendy; Feng Zhou | Zendy; Tetsuo Ogawa | Zendy; Charles R. Goodlett | Zendy; Jenny Ruiz | Zendy

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Alcohol exposure alters cell cycle and apoptotic events during early neurulation

Author(s) -

Benjamin Anthony,

Feng Zhou,

Tetsuo Ogawa,

Charles R. Goodlett,

Jenny Ruiz

Publication year - 2008

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agm166

Subject(s) - cell cycle , biology , dna fragmentation , apoptosis , apoptotic dna fragmentation , cell growth , microbiology and biotechnology , cyclin d1 , propidium iodide , fragmentation (computing) , s phase , cyclin e , cell cycle checkpoint , cyclin a , dna damage , programmed cell death , proliferating cell nuclear antigen , genetics , dna , eukaryotic dna replication , ecology

Fetal alcohol exposure causes growth deficits, microencephaly, and neurological abnormalities. Although the effects of alcohol on developmental delay and growth-related deficits have been hypothesized, little is understood about how alcohol alters, in particular, the cyclin pathway within the cell cycle, which is critical to proliferation and apoptotic control. In this study, we examined cell cycle proteins pertinent to the G1-S phase transition and apoptosis, to determine if cell cycle misregulation can be attributed to apoptotic induction and growth defects.

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