CARDIAC OVEREXPRESSION OF METALLOTHIONEIN RESCUES CHRONIC ALCOHOL INTAKE-INDUCED CARDIOMYOCYTE DYSFUNCTION: ROLE OF AKT, MAMMALIAN TARGET OF RAPAMYCIN AND RIBOSOMAL P70S6 KINASE | Zendy

Qun Li | Zendy; Jun Ren | Zendy

Open Access

CARDIAC OVEREXPRESSION OF METALLOTHIONEIN RESCUES CHRONIC ALCOHOL INTAKE-INDUCED CARDIOMYOCYTE DYSFUNCTION: ROLE OF AKT, MAMMALIAN TARGET OF RAPAMYCIN AND RIBOSOMAL P70S6 KINASE

Author(s) -

Qun Li,

Jun Ren

Publication year - 2006

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agl080

Subject(s) - protein kinase b , pi3k/akt/mtor pathway , endocrinology , ribosomal s6 kinase , medicine , metallothionein , ribosomal protein s6 , akt1 , phosphorylation , kinase , insulin receptor , biology , insulin , mtorc1 , p70 s6 kinase 1 , signal transduction , biochemistry , insulin resistance , gene

Reduced insulin sensitivity following alcohol intake plays a role in alcohol-induced organ damage although its precise mechanism is undefined. This study was designed to examine the effect of cardiac overexpression of the antioxidant metallothionein on alcohol-induced cardiac contractile dysfunction and post-receptor insulin signaling.

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