DIFFERENT ALLELE-DISTRIBUTION OF MTHFR 677 C → T AND MTHFR −393 C → A IN PATIENTS CLASSIFIED ACCORDING TO SUBTYPES OF LESCH'S TYPOLOGY | Zendy

Dominikus Bönsch | Zendy; Kristina Bayerlein | Zendy; Udo Reulbach | Zendy; Roland Fiszer | Zendy; Thomas Hillemacher | Zendy; Wolfgang Sperling | Zendy; Johannes Kornhuber | Zendy; Stefan Bleich | Zendy

Open Access

DIFFERENT ALLELE-DISTRIBUTION OF MTHFR 677 C → T AND MTHFR −393 C → A IN PATIENTS CLASSIFIED ACCORDING TO SUBTYPES OF LESCH'S TYPOLOGY

Author(s) -

Dominikus Bönsch,

Kristina Bayerlein,

Udo Reulbach,

Roland Fiszer,

Thomas Hillemacher,

Wolfgang Sperling,

Johannes Kornhuber,

Stefan Bleich

Publication year - 2006

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agl024

Subject(s) - methylenetetrahydrofolate reductase , medicine , genotype , homocysteine , allele , gastroenterology , endocrinology , genetics , biology , gene

The typology by Lesch distinguishes between four subtypes: type 1 (model of allergy), type 2 (model of anxiety or conflict), type 3 (alcohol as an antidepressant), and type 4 (alcohol as adaptation). Taking into account that alcohol dependence is associated with elevated homocysteine levels, this study was undertaken to investigate different MTHFR (methylenetetrahydrofolate reductase) genotypes related to homocysteine metabolism in patients with alcohol dependence who were classified according to Lesch's typology (LT).

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