THE EFFECTS OF ACETALDEHYDE IN VITRO ON PROTEASOME ACTIVITIES AND ITS POTENTIAL INVOLVEMENT AFTER ALCOHOLIZATION OF RATS BY INHALATION OF ETHANOL VAPOURS | Zendy

Hélène Rouach | Zendy; Evelyne Andraud | Zendy; Gilles Aufrère | Zendy; Françoise Beaugé | Zendy

Open Access

THE EFFECTS OF ACETALDEHYDE IN VITRO ON PROTEASOME ACTIVITIES AND ITS POTENTIAL INVOLVEMENT AFTER ALCOHOLIZATION OF RATS BY INHALATION OF ETHANOL VAPOURS

Author(s) -

Hélène Rouach,

Evelyne Andraud,

Gilles Aufrère,

Françoise Beaugé

Publication year - 2005

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agh174

Subject(s) - acetaldehyde , proteasome , chemistry , ethanol , lipid peroxidation , inhalation , biochemistry , cyp2e1 , pharmacology , aldehyde dehydrogenase , in vitro , oxidative stress , microsome , enzyme , biology , medicine , anesthesia

Some models of chronic ethanol administration resulted in decreased proteasome activities. The mechanisms still remain speculative. In the present study, we tested another model of alcoholization with high blood alcohol levels (BALs) and high acetaldehyde fluxes as well as the in vitro effect of acetaldehyde on proteasome. Methods/

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