EFFECTS OF NALTREXONE ON THE ETHANOL-INDUCED CHANGES IN THE RAT CENTRAL DOPAMINERGIC SYSTEM | Zendy

YoungKyun Lee | Zendy

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EFFECTS OF NALTREXONE ON THE ETHANOL-INDUCED CHANGES IN THE RAT CENTRAL DOPAMINERGIC SYSTEM

Author(s) -

YoungKyun Lee

Publication year - 2005

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agh163

Subject(s) - ventral tegmental area , dopaminergic , nucleus accumbens , naltrexone , dopamine , mesolimbic pathway , chemistry , striatum , substantia nigra , pharmacology , dopaminergic pathways , tyrosine hydroxylase , endogenous opioid , neurochemical , endocrinology , medicine , opioid , biochemistry , receptor

The opioid antagonist naltrexone may reduce ethanol reward, but the underlying neurochemical mechanisms has yet to be clarified. The afferent projections to the nucleus accumbens from the ventral tegmental area (VTA) provide a potential substrate by which endogenous opioids may modulate the dopaminergic rewarding effects of ethanol. We assessed mRNA levels of tyrosine hydroxylase (TH), a major regulatory enzyme in the dopamine synthesis and levels of dopamine and its metabolites after chronic ethanol administration with and without concomitant naltrexone.

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