Open AccessDLPC ATTENUATES ALCOHOL-INDUCED CYTOTOXICITY IN HEPG2 CELLS EXPRESSING CYP2E1
Author(s) -
Youqing Xu,
Maria A. Leo,
Charles S. Lieber
Publication year - 2005
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/agh142
Subject(s) - cytotoxicity , alcohol , pharmacology , cyp2e1 , ethanol , chemistry , medicine , biochemistry , in vitro , enzyme , cytochrome p450
Alcoholic liver injury was shown to result largely from oxidative stress generated by ethanol metabolism via cytochrome P4502E1 (CYP2E1). Our aim was to determine whether this could be overcome by using dilinoleoylphosphatidylcholine (DLPC), an innocuous antioxidant extracted from soybeans.
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