EFFECTS OF ACETALDEHYDE AND TNFα ON THE INHIBITORY KAPPA B- α PROTEIN AND NUCLEAR FACTOR KAPPA B ACTIVATION IN HEPATIC STELLATE CELLS | Zendy

Gennadiy Novitskiy | Zendy; Rajani Ravi | Zendy; James J. Potter | Zendy; Lynda Rennie-Tankersley | Zendy; Lan Wang | Zendy; Esteban Mezey | Zendy

Open Access

EFFECTS OF ACETALDEHYDE AND TNFα ON THE INHIBITORY KAPPA B- α PROTEIN AND NUCLEAR FACTOR KAPPA B ACTIVATION IN HEPATIC STELLATE CELLS

Author(s) -

Gennadiy Novitskiy,

Rajani Ravi,

James J. Potter,

Lynda Rennie-Tankersley,

Lan Wang,

Esteban Mezey

Publication year - 2004

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agh116

Subject(s) - acetaldehyde , hepatic stellate cell , tumor necrosis factor alpha , chemistry , alcoholic liver disease , iκb kinase , nfkb1 , alcoholic hepatitis , nf κb , endocrinology , liver injury , medicine , microbiology and biotechnology , inflammation , biology , biochemistry , ethanol , transcription factor , cirrhosis , gene

Increased plasma tumour necrosis alpha (TNFalpha) and elevated monocyte nuclear factor kappa B (NF-kappaB) are associated with liver injury and inflammation in models of alcoholic liver disease and are found to be elevated in monocytes of patients with alcoholic hepatitis. Acetaldehyde enhances, whereas TNFalpha inhibits, transcription of the type I collagen promoters and type I collagen production. NF-kappaB, an inhibitor of the type I collagen promoters, is increased by both acetaldehyde and TNFalpha. This study determined the effects of acetaldehyde in comparison to the effects of TNFalpha on inhibitory kappa B-alpha (IkappaB-alpha) protein and NF-kappaB activation in hepatic stellate cells.

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