THE ROLE OF POLYMORPHISMS OF GLUTATHIONE S-TRANSFERASES GSTM1, M3, P1, T1 AND A1 IN SUSCEPTIBILITY TO ALCOHOLIC LIVER DISEASE | Zendy

Alison Brind | Zendy; Adam Hurlstone | Zendy; D. EDRISINGHE | Zendy; Ian Gilmore | Zendy; Neil Fisher | Zendy; Munir Pirmohamed | Zendy; Anthony A. Fryer | Zendy

Open Access

THE ROLE OF POLYMORPHISMS OF GLUTATHIONE S-TRANSFERASES GSTM1, M3, P1, T1 AND A1 IN SUSCEPTIBILITY TO ALCOHOLIC LIVER DISEASE

Author(s) -

Alison Brind,

Adam Hurlstone,

D. EDRISINGHE,

Ian Gilmore,

Neil Fisher,

Munir Pirmohamed,

Anthony A. Fryer

Publication year - 2004

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agh105

Subject(s) - alcoholic liver disease , disease , glutathione , medicine , psychology , gastroenterology , biology , biochemistry , enzyme , cirrhosis

Oxidant stress is proposed to be an important pathogenic factor in liver damage related to alcohol. The glutathione S-transferases (GSTs) are a group of polymorphic enzymes that are important in protection against oxidant stress. As there is evidence for genetic susceptibility to alcohol-related liver disease we have compared the frequency of polymorphisms of GSTM1, M3, P1, T1 and A1 by polymerase chain reaction (PCR) on leucocyte DNA in patients from North Staffordshire, Birmingham and Liverpool with alcohol-related chronic liver disease heavy drinking and normal local controls.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research