ACETALDEHYDE-INDUCED CARDIAC CONTRACTILE DYSFUNCTION MAY BE ALLEVIATED BY VITAMIN B1 BUT NOT BY VITAMINS B6 OR B12 | Zendy

Nicholas S. Aberle | Zendy; Larry Burd | Zendy; Bonnie H Zhao | Zendy; Jun Ren | Zendy

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ACETALDEHYDE-INDUCED CARDIAC CONTRACTILE DYSFUNCTION MAY BE ALLEVIATED BY VITAMIN B1 BUT NOT BY VITAMINS B6 OR B12

Author(s) -

Nicholas S. Aberle,

Larry Burd,

Bonnie H Zhao,

Jun Ren

Publication year - 2004

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agh085

Subject(s) - alcoholic cardiomyopathy , medicine , endocrinology , vitamin , contractility , myocyte , apoptosis , acetaldehyde , vitamin b12 , vitamin e , chemistry , antioxidant , biochemistry , cardiomyopathy , ethanol , heart failure

Chronic alcohol exposure leads to a deficiency of group B vitamins and increased risk of alcoholic cardiomyopathy characterized by impaired ventricular contractility. This study was designed to examine the effect of group B vitamin supplementation on short-term exposure of the main alcohol metabolite acetaldehyde (ACA)-induced cardiac contractile dysfunction in rat ventricular myocytes.

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